Tuesday, February 16, 2010

International Stem Cell Corporation Provides Strategic Update on the Company’s Cornea Transplantation Program

OCEANSIDE, CA – February 16, 2010 – International Stem Cell Corporation (ISCO.OB), www.intlstemcell.com, announced today that multiple international meetings taking place between ISCO’s executive management and researchers and clinicians from commercial entities in both Asia and Europe revealed significant clinical-commercial opportunities for the company’s stem cell-derived human cornea technology in those regions.

ISCO has discovered and filed for patents on a cell culture process for the synthesis of fully human, cornea-like structures using either its proprietary human parthenogenic stem cell (hpSC) technology or human embryonic stem cells. The structures are grown to clear hollow spheres with a size of 8-10 mm in diameter and contain tissues and cells similar to those found in normal human corneal tissue. Portions or all of these structures may be suitable for cornea transplantation in humans. Permeability and ocular histology testing has demonstrated compatibility with natural corneas. Future steps include scale-up of the manufacturing process and IND-enabling studies, to be conducted domestically and through international collaborations.

Cornea-related loss or reduction of vision can be caused by physical injuries, infections and a range of degenerative diseases that affect up to 10 million people worldwide. ISCO’s corneal structure may fit into existing medical applications where the surgical techniques are well established. Cornea transplantation has been refined greatly and is now typically performed as a one-two hour outpatient procedure using donated corneas from human cadavers. While most operations previously involved the entire corneal structure it is now common to selectively replace solely the damaged portion.

ISCO’s parthenogenic stem cell technology enables synthesis of corneal tissue that is immune matched for millions of people. This may significantly reduce the rejection rates of 15-30% experienced in current medical practice.

In the US 52,487 transplantations were performed in 2008. However, a shortage of corneal tissue has been a significant problem in much of the rest of the world. Only 3,000-4,000 procedures were performed annually in the UK and Germany due to limited cornea supply. In Asia, the shortage of corneas has been an even greater problem. For example, in Japan during a ten-year period only 16,000 transplantations were performed. China has had over 2 million patients on waiting lists yet only a few thousand procedures have been performed annually. Over 3 million Indians are reported to be blind due to corneal defects.

Dr Radhika Tandon, Professor of Ophthalmology and Officer-in-charge at the National Eye Bank, All India Institute of Medical Sciences (AIIMS) in New Delhi says: “Corneal vision impairment is a large medical problem in India and other developing countries. India has access to less than 20,000 suitable corneas per year yet would need 200,000 corneas to take care of the existing backlog and the new cases added each year. Supply of synthetic human corneas would alleviate the problem and provide great socio-economic benefit by enabling millions of Indians to get back to work and live a more normal life.”

Brian Lundstrom, ISCO’s President, says: “Given the substantial unmet medical need for human corneas in Asia and Europe, ISCO has commenced a targeted effort to partner with clinical development and commercialization partners in these regions. We believe clinical development in this area is particularly attractive given the rapid and hard end points of vision restoration, large available patient pools and modest competition from alternative technologies, particularly such involving live corneas.”

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, www.internationalstemcell.com

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS

International Stem Cell Corporation

Kenneth C. Aldrich, Chairman

760-940-6383

kaldrich@intlstemcell.com

Or

Brian Lundstrom, President

760-940-6383

bl@intlstemcell.com

Thursday, February 4, 2010

International Stem Cell Corporation Opens Facility for Development and Production of Clinical-Grade Stem Cell Products

OCEANSIDE, CA – February 4, 2010 – International Stem Cell Corporation (ISCO.OB), www.internationalstemcell.com, announced today that its new cell production facility has passed final building inspection, which will enable development and manufacturing of the company and its partners’ clinical-grade stem cell products.

ISCO has designed and built a unique cell manufacturing facility in Oceanside, California consisting of separate “suites” for development and production of different cell types from the company’s proprietary human parthenogenic stem cell (hpSC) technology. The facility is located in close proximity to the fertility clinics that provide donated human eggs (oocytes) under ISCO’s recently-established partnerships and also near leading Californian research institutions with whom ISCO collaborates on fundamental stem cell biology and therapeutic applications.

ISCO will implement its parthenogenic stem cell processes at this facility during 2010 and adopt current good manufacturing practice (cGMP) standards.In parallel, ISCO will collaborate with world-leading scientists to demonstrate the therapeutic applicability and the potential immune-rejection advantages of hpSC lines relative to other stem cell classes.

Like embryonic stem cells (ESCs), hpSCs are pluripotent (i.e. have the capacity to become almost any cell type in the body), yet avoid ethical issues associated with destruction or use of viable human embryos. Unlike induced pluripotent stem cells (iPSs), hpSCs do not require manipulation of gene expression back to a less differentiated stage, which may prove to be a safety or regulatory obstacle. However, unlike both ESCs and iPSs, hpSCs can be created in a homozygous form such that each line can be an immunological match for millions of patients.

Dr. Andrey Semechkin, ISCO’s CEO, says: “Our ability to work in this modern facility gives International Stem Cell Corporation the capacity to generate the world’s first cGMP quality hpSC lines. It marks an important milestone since it both expands the resources available to our scientists and expands ISCO’s ability to execute on its plan to become the premier provider of immune-matched stem cells to the global research community. Through these cells, ISCO will be able to treat a range of degenerative diseases in genetically diverse populations around the world.”

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in the creation of parthenogenetic human stem cells from unfertilized eggs (oocytes). Like embryonic stem cells (ESCs), hpSCs are pluripotent (i.e. have the capacity to become almost any cell type in the body), yet avoid ethical issues associated with use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS:
Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com