Wednesday, April 1, 2015
Albrecht M. Müller from University of Würzburg, Würzburg, Germany publishes paper show parthenogenetic stem cells are less immunogenic than embryonic stem cells
Albrecht Müller of University of Würzburg, Germany publishes paper showing that parthenogenetic stem cells are less immunogenic than embryonic stem cells
In the paper "Human parthenogenetic embryonic stem cell-derived neural stem cells express HLA-G and show unique resistance to NK cell-mediated killing." in March 2015 edition of Mol.Med. Prof. Muller shows using a number of analytical methods that parthenogenetic stem cells stimulate a lower immune response compared with embryonic stem cells. He finds that the lack of parternal imprinting in parthenogenetic stem cells can actually be of benefit immunologically and that this advantage is not only present in the pluripotent stem cells, but also their progeny including neural stem cells, the very same cells that ISCO intends to use to treat Parkinson's patients in the upcoming clinical trial in Australia.
The abstract can be found on pubmed (http://www.ncbi.nlm.nih.gov/pubmed/25811991?dopt=Abstract)