International Stem Cell Corporation to Present at International Society for Cellular Therapy Annual Meeting

CARLSBAD, CA – (May 27, 2015) - International Stem Cell Corporation (OTCQB:ISCO), a California-based biotechnology company developing novel stem cell based therapies and biomedical products, announced today that the company has been selected to give an oral presentation on its preclinical studies in Parkinson’s at the 21st annual meeting of the International Society for Cellular Therapy in Las Vegas. ISCO's chief scientific officer, Ruslan Semechkin, Ph.D., will discuss the data at the "Regeneration and Nervous System Repair" session at 11:45 a.m. on May 30, 2015 in a presentation entitled ”Human Parthenogenetic Derived Neural Stem Cells for the Treatment of Parkinson’s Disease.”

ISCO has built an extensive preclinical dataset from a series of GLP and non-GLP studies on human parthenogenetic neural stem cells (hpNSC). The dataset includes safety studies, where hpNSC were transplanted into the brains of healthy animals, and proof-of-principle studies where the cells were transplanted into animals with induced Parkinson's disease symptoms. The studies show that hpNSCs are well tolerated with no evidence of tumor formation even at very high doses and have the ability to protect and recover neurons, increase dopamine levels and improve the motor function. The Company has submitted a CTX application to the Australian regulatory authorities and plans to begin the phase 1/2a clinical study in Parkinson’s disease within the next few months.

The International Society for Cellular Therapy (ISCT) is a global association driving the translation of scientific research to deliver innovative cellular therapies to patients. ISCT is one of the only organizations focused on pre-clinical and translational aspects of developing cell therapy products. As such, ISCT helps academic, government and biotech/pharma sectors transform research into practice and product. Over 1200 international delegates including clinicians, scientists and regulatory experts are expected to attend this year’s meeting.

About human parthenogenetic neural stem cell (hpNSC)

hpNSCs are a novel therapeutic cellular product derived from the Company's proprietary human pluripotent stem cells. Neural stem cells work to repair the brain in several ways. In response to signals released by damaged tissue neural stem cells release a range of molecules that reduce inflammation and trigger the recovery process. Neural stem cells also have the ability to generate new cells to replace those that are either dead or dying, enabling the formation of new tissue.

About Parkinson’s disease

According to the Parkinson's Disease Foundation, an estimated seven to 10 million people worldwide live with Parkinson's disease, with as many as one million of those in the United States alone, more than the combined total of people diagnosed with multiple sclerosis, muscular dystrophy, and Lou Gehrig's disease. Parkinson's disease is a progressive neurodegenerative disorder resulting from the gradual loss of certain neurons responsible for producing dopamine, and is characterized by symptoms including tremors at rest, rigidity and impaired movement.

The standard of care for the treatment of PD symptoms is oral levodopa (L-dopa). Oral dosing of L-dopa is associated with wide variability in the timing and amount of L-dopa absorption into the bloodstream, leading to the unreliable control of symptoms resulting in the emergence of OFF episodes, periods of time during which Parkinson's disease symptoms reemerge despite L-dopa treatment. These OFF episodes, which increase in frequency and severity during the course of the disease, are experienced by a majority of PD patients and are considered one of the greatest unmet medical needs facing PD patients.

About International Stem Cell Corporation

International Stem Cell Corporation is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenetic homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCell™. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (www.lifelinecelltech.com), and stem cell-based skin care products through its subsidiary Lifeline Skin Care (www.lifelineskincare.com). More information is available at www.internationalstemcell.comand companyblog.intlstemcell.com.

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Safe harbor statement

Statements pertaining to anticipated developments, expected clinical studies (including timing and results), progress of research and development, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

Contacts:

International Stem Cell Corporation

Simon Craw, Ph.D., Executive Vice President
Phone: 760-940-6383
Email: ir@intlstemcell.com

Ruslan Semechkin, Ph.D., Chief Scientific Officer
Phone: 760-940-6383
Email: ras@intlstemcell.com

Media

Tony Russo, Ph.D.
Phone: 212-845-4251
Email: tony.russo@russopartnersllc.com

Christopher Hippolyte
Phone: (646)942-5634
Email: chris.hippolyte@russopartnersllc.com